Responsabilidad por los daños causados durante la etapa de formación del contrato estatal

53 páginasEl artículo identifica y explica los principales daños ocasionados por la administración durante la etapa de formación del contrato estatal, así como las consecuencias que acarrea la violación del deber de planeación y la generación de hechos cumplidos, puntualizando su naturaleza jurídica, concepto y reparación, de cara a la normativa, jurisprudencia y doctrina autorizada.This article identifies and explains the main damages caused by the administration during the stage formation of the state contract, as well consequences that result from the violation of the planning duty and the generation of fulfilled facts, unraveling in its legal nature, concept and reparation, according regulations, jurisprudence and authoritative doctrine.Magíster en DerechoMaestrí

En marcha con las TIC : experiencias con las tecnologías educativas en Extremadura

Se recopilan aportaciones y experiencias de profesionales de la educación extremeños que han empleado programas y herramientas para crear materiales que sirvan para su trabajo en el aula y para promocionar el aprendizaje a través del uso del ordenador.ExtremaduraConsejería de Educación. Dirección General de Política Educativa; Calle Delgado Valencia, 6; 06800 Mérida (Badajoz); +34924006714; +34924006716; [email protected]

Contemporary use of cefazolin for MSSA infective endocarditis: analysis of a national prospective cohort

Objectives: This study aimed to assess the real use of cefazolin for methicillin-susceptible Staphylococcus aureus (MSSA) infective endocarditis (IE) in the Spanish National Endocarditis Database (GAMES) and to compare it with antistaphylococcal penicillin (ASP). Methods: Prospective cohort study with retrospective analysis of a cohort of MSSA IE treated with cloxacillin and/or cefazolin. Outcomes assessed were relapse; intra-hospital, overall, and endocarditis-related mortality; and adverse events. Risk of renal toxicity with each treatment was evaluated separately. Results: We included 631 IE episodes caused by MSSA treated with cloxacillin and/or cefazolin. Antibiotic treatment was cloxacillin, cefazolin, or both in 537 (85%), 57 (9%), and 37 (6%) episodes, respectively. Patients treated with cefazolin had significantly higher rates of comorbidities (median Charlson Index 7, P <0.01) and previous renal failure (57.9%, P <0.01). Patients treated with cloxacillin presented higher rates of septic shock (25%, P = 0.033) and new-onset or worsening renal failure (47.3%, P = 0.024) with significantly higher rates of in-hospital mortality (38.5%, P = 0.017). One-year IE-related mortality and rate of relapses were similar between treatment groups. None of the treatments were identified as risk or protective factors. Conclusion: Our results suggest that cefazolin is a valuable option for the treatment of MSSA IE, without differences in 1-year mortality or relapses compared with cloxacillin, and might be considered equally effective